感染制御学研究室

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研究テーマ感染症の制圧にむけた基礎~応用研究

 微生物は生態系の維持、食品、医薬品の製造等に欠くことができない存在です。私たちの健康は常在菌なくして成り立ちません。一方で、微生物の一部はヒトにがんや感染症を引き起こします。当研究室では微生物を上手に利用したり、微生物が病原性を発揮する分子メカニズムを解明したり、感染症を治療するための新しい方法を開発する研究を行っています。より豊かで健康な暮らしを実現するために一緒に挑戦してみませんか。

キーワード

宿主-病原体相互作用 (Host-pathogen interaction) 
医療関連感染 (Healthcare associated infections)
感染制御 (Infection control) 
病原微生物 (Pathogenic microbes) 
病原性(Virulence)

配属学生

大学院生 0名
学部学生 6年次生:15名、5年次生:14名、4年次生:14名

スタッフ

駒野 淳
駒野 淳
教授 / 博士(医学)
担当科目
微生物学、生物学実習 (2年)、特別演習・実習 (4年、5年、6年) 特別演習(大学院)、特別研究演習Ⅰ、Ⅱ、Ⅲ(大学院)
所属学会および社会活動
日本薬学会、日本分子生物学会、日本癌学会、日本感染症学会、日本ウイルス学会
Mail:
j.komano@)gly.oups.ac.jp
reseachmap:
https://researchmap.jp/read0165644/
宮本 勝城
宮本 勝城
准教授 / 博士(薬学)
担当科目
ゲノム医科学、生物科学実習 (3年)、特別演習・実習 (4年、5年、6年)、 生物科学特論(大学院)、領域統合型先端科学特論(大学院)、分子構造・機能解析学Ⅰ、Ⅱ、Ⅲ(大学院)、予防薬学特論Ⅱ(大学院)、特別演習(大学院)、特別研究演習Ⅰ、Ⅱ、Ⅲ(大学院)
所属学会および社会活動
日本薬学会、日本細菌学会、日本農芸化学会、日本キチン・キトサン学会(評議員)、日本鉄バイオサイエンス学会、日本放線菌学会、アメリカ微生物学会
Mail:
miyamoto@gly.oups.ac.jp
reseachmap:
https://researchmap.jp/read0033575/
土屋 孝弘
土屋 孝弘
講師 / 博士(薬学)
担当科目
免疫学 (3年)、生物学実習 (2年)、特別演習・実習 (4年、5年、6年)、 生物科学特論(大学院)、特別演習(大学院)、特別研究演習Ⅰ、Ⅱ、Ⅲ(大学院)
所属学会および社会活動
日本薬学会、日本細菌学会、日本免疫学会
Mail:
tsuchiya@gly.oups.ac.jp
reseachmap:
https://researchmap.jp/read0197480/

研究内容

(1)感染症に対する新たな治療戦略の開発研究 Development of novel strategies to control pathogenic microbe infections

 病原微生物の感染は、感染症やがんの原因です。抗菌薬や抗ウイルス薬の開発によって感染症の治療は著しく進歩しました。ところが、近年治療薬が効かない病原体が社会問題になっています。特に多数の抗菌薬に耐性になった細菌は医療関連感染を引き起こし、近代医療を妨げる大きな要因です。当研究室では、多剤耐性菌を中心に、未だ根治療法が確立していない病原体等に対する新たな制御方法を探索します。

(2)宿主-病原体相互作用の解析を通じた病原性発揮メカニズムの解明 Elucidation of molecular mechanism of the virulence of pathogenic microbes via host-pathogen interactions

 我々は様々な微生物に絶えず曝露されていますが、ほとんどの場合は健康を害することはありません。異物が体内に侵入しても、それを排除し恒常性を維持する免疫機構が私たちの体に備えられているからです。しかし、病原細菌は病原因子よって宿主を攻撃したり、免疫機構から逃れることによって感染症を引き起こします。当研究室では病原体がどのようにして宿主を攻撃するのか、宿主の免疫から逃れるのかを、病原体と宿主側の両面から分子~個体レベルで解析します。

参考論文

  1. Biometals, 30:203-216, 2017; J Gen Virol., 98:643-651, 2017 ;Chem Med Chem., 11:2320-2326, 2016 ;Cancer Sci., 105:211-218, 2014;Leukemia, 27:1621-1627, 2013
  2. J Virol Methods., 252:86-93, 2017; J Infect Dis., 211:879-888, 2015;J Acquir Immune Defic Syndr., 64:154-162, 2013;Microbiol Immunol., 56:107-116, 2012

代表的論文

2019年

  1. Kojima Y, Furubayashi K, Kawahata T, Mori H, and Komano J: Circulation of distinct Treponema pallidum strains in individuals with heterosexual orientation and men who have sex with men (MSM)., J Clin Microbiol., 57:e01148-18, 2019
  2. Kurata T, Uchino K, Hotta C, Ogura A, Miyoshi T, Ogawa T, Kanbayashi D, Tanaka T, Yumisashi T, Komano J: Clinical value of enzyme immunoassay that detects rubella-specific immunoglobulin M immediately after disease onset., Microbiol Immunol., 63:32-35, 2019

2018年

  1. Kawano H, Miyamoto K, Yasunobe M, Murata M, Yamahata E, Yamaguchi R, Miyaki Y, Tsuchiya T, Tanabe T, Funahashi T, Tsujibo H: Identification of the heme acquisition system in Vibrio vulnificus M2799., Microb Pathog., 117:100-108, 2018
  2. Tanabe T, Isshiki A, Miyamoto K, Tsujibo H, Yamamoto S, Funahashi T: Transcriptional regulation of the ferric aerobactin receptor gene by a GntR-like repressor IutR in Vibrio furnissii., FEMS Microbiol Lett., 365:fny220, 2018
  3. Sakon N, Sadamatsu K, Shinkai T, Hamajima Y, Yoshitomi H, Matsushima Y, Taerasoma F, Nakamura A, Takada R, Komano J, Nagasawa K, Katayama K, Kimura H: Molecular epidemiology of large foodborne outbreaks due to human norovirus GII.P17GII.17-contaminated dried shredded seaweed (nori)., Emerg Infect Dis., 24:920-923, 2018
  4. Komano J: Establishment of a secure differentiation and de-differentiation-inducing method by protein transduction system LENA (Review)., Impact., 2018:82-84, 2018
  5. Kariya N, Sakon N, Komano J, Tomono K, Iso H: Current Prevention and Control of Health Care-associated Infections in Long-term Care Facilities for Elderly in Japan., J Infect Chemother., pii: S1341-321X(17)30304-30305, 2018
  6. Sakon N, Komano J, Omori R: High transmission potential of norovirus among infants and school children during 2016-201 season in Osaka, Japan., Euro Surveill., 23. doi: 10.2807/1560-7917.ES.2018.23.6.18-00029. 2018

2017年

  1. Kawano H, Miyamoto K, Negoro M, Zushi E, Tsuchiya T, Tanabe T, Funahashi T, Tsujibo H: IutB participates in the ferric-vulnibactin utilization system in Vibrio vulnificus M2799., Biometals, 30:203-216, 2017
  2. Tomoo K, Miki Y, Morioka H, Seike K, Ishida T, Ikenishi S, Miyamoto K, Hasegawa T, Yamano A, Hamada K, Tsujibo H: Crystal structure of the solute-binding protein BxlE from Streptomyces thermoviolaceus OPC-520 complexed with xylobiose., J. Biochem., 161:493-501, 2017
  3. Kanbayashi D, Kurata T, Takahashi K, Kase T, Komano J: A novel cell-based high throughput assay to determine neutralizing antibody titers against circulating strains of rubella virus., J Virol Methods., 252:86-93, 2017
  4. Hiroi S, Kuhara M, Kishi Y, Ono K, Matsuzawa S, Yamamoto N, Komano J: Human monoclonal antibodies neutralizing influenza virus A/H1N1pdm09 and seasonal A/H1N1 strains – Distinct Ig gene repertoires with a similar action mechanism., Immunobiol., 7 pii: S0171-2985(17)30181-X. doi: 10.1016/j.imbio.2017.10.040., 201
  5. Sakon N, Miyamoto R, Komano J: An Infant with Acute Gastroenteritis Caused by a Secodary Infection with a Rotarix-derived Strain., Euro J Pediatr., 176:1275-1278, 2017
  6. Martin CW, Hu Y, Chen H, Podkolzin AT, Zaytseva EV, Komano J, Sakon N, Poovorawan Y, Vongpunsawad S, Thanusuwannasak T, Hewitt J, Collins N, Vinjé J, Pang XL, Lee BE, de Graaf M, Vennema H, Koopmans MPG, Niendorf S, Hung T, Kwok K, Cheung K, Poljsak-Prijatelj M, Steyer A, White PA, Mans J, Lee N, Chan PKS: Global Spread of Norovirus Genogroup II Genotype 17 Kawasaki 308, 2014—2016., Emerg Infect Dis., 23:1359-1354, 2017
  7. Nakata K, Takeda S, Tanaka A, Kwang J, Komano J: Antiviral activity of acid beta-glucosidase 1 on enterovirus 71, a causative agent of Hand-Foot-Mouth disease (HFMD)., J Gen Virol., 98:643-651, 2017
  8. Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T: Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response., Proc Natl Acad Sci U S A., 114:2681-2686, 2017

2016年

  1. Urano E, Miyauchi K, Kojima Y, Hamatake M, Ablan SD, Fudo S, Freed EO, Hoshino T, Komano J: A triazinone derivative inhibits HIV-1 replication by interfering with reverse transcriptase activity., Chem Med Chem., 11:2320-2326, 2016
  2. Takeda S, Takizawa M, Miyauchi K, Urano E, Fujino M, Murakami T, Murakami T, Komano J: Conformational Properties of the Third Variable Loop of HIV-1AD8 Envelope Glycoprotein in the Liganded Conditions., Biochem Biophys Res Commun., 475:113-118, 2016
  3. Hoshino T, Matsuo K, Komano J, Maeda F, and Takekoshi M: Enhancement of the stability of single chain Fv molecules with the amino acid substitutions predicted by high-performance computer., Asia Pacific Biotech News, 20:32-37, 2016

2015年

  1. Tanabe T, Miyamoto K, Tsujibo H, Yamamoto S, Funahashi T: The small RNA Spot 42 regulates the expression of the type III secretion system 1 (T3SS1) chaperone protein VP1682 in Vibrio parahaemolyticus., FEMS Microbiol. Lett., 362:fnv173, 2015
  2. Miyano N, Igarashi T, Kawano H, Miyamoto K, Tsuchiya T, Tomoo K, Tsujibo H: Expression, purification, crystallization and X-ray crystallographic analysis of the periplasmic binding protein VatD from Vibrio vulnificus M2799., Acta Crystallogr. F Struct. Biol. Commun., 71:1078-1082, 2015
  3. Mori H, Kojima Y, Kawahata T, Matuura M, Uno K, Komano J: A cluster of rapid disease progressors upon primary HIV-1 infection shared a novel variant with mutations in the p6gag/pol and pol/vif genes., AIDS, 29:1717-1719, 2015
  4. Kojima Y, Kawahata T, Mori H, Furubayashi K, Taniguchi Y, Itoda I, Komano J: Identification of novel recombinant forms of hepatitis B virus generated from genotypes Ae and G in HIV-positive Japanese MSM., 60-767, 2015 AIDS Res Human Retroviruses., 31:7
  5. Kurata T, Kanbayashi D, Nishimura H, Komano J, Kase T, Takahashi K: Increased reports of measles in a low endemic region of Japan during a rubella outbreak in 2013., Am J Infect Control., 43:653-655, 2015
  6. Nakata K, Kashiwagi M, Masuda M, Shigehara S, Oba C, S, Kase T, Komano J: A child with acute encephalopathy associated with quadruple virsl infection., Front Pediatr., 3:26. doi: 10.3389/fped.2015.00026. eCollection 2015, 2015
  7. Takeda S, Hisano M, Komano J, Yamamoto H, Sago H, Yamaguchi K: Influenza vaccination during pregnancy and its usefulness to mothers and their young infants (Review)., J Infect Chemother., 21:238-246, 2015
  8. Sakon N, Yamazaki K, Nakata K, Kanbayashi D, Yoda T, Mantani M, Kase T, Takahashi K, .Komano J: Impact of Herd Immunity on the Circulatory Dynamism of Norovirus: A 10-year Longitudinal Study of Viral Acute Gastroenteritis., J Infect Dis., 211:879-888, 2015

2014年

  1. Funahashi T, Tanabe T, Maki J, Miyamoto K, Tsujibo H, Yamamoto S: Identification and characterization of Aeromonas hydrophila genes encoding the outer membrane receptor of ferrioxamine B and an AraC-type transcriptional regulator., Biosci. Biotechnol. Biochem., 78:1777-1787, 2014
  2. Kawano H, Miyamoto K, Yasunobe M, Murata M, Myojin T, Tsuchiya T, Tanabe T, Funahashi T, Sato T, Azuma T, Mino Y, Tsujibo H: The RND protein is involved in the vulnibactin export system in Vibrio vulnificus M2799., Microb. Pathog., 75:59-67, 2014
  3. Tanabe T, Kato A, Shiuchi K, Miyamoto K, Tsujibo H, Maki J, Yamamoto S, Funahashi T: Regulation of the expression of the Vibrio parahaemolyticus peuA gene encoding an alternative ferric enterobactin receptor., PLoS One, 9:e105749, 2014
  4. Kawabuchi-Kurata T, Misaki T, Suehiro Y, Komano AJ, Kase T, Takahashi, K: Longitudinal study on respiratory viral co-infections in infants aged 0-2 years., Jpn J Infect Dis., 67:216-220, 2014
  5. Kurata T, Kanbayashi D, Komano J., Kase T, Takahashi K: Pitfalls of National Surveillance Systems for Vaccine-associated Measles., Am J Med., 127:e3-4, 2014
  6. Kurata T, Kanbayashi D, Kinoshita H, Arai S, Matsui Y, Fukumura K, Matsumoto H, Odaira F, Murata A, Konishi M, Yamamoto K, Nakano R, Ohara T, Otsuru E, Komano J., Kase T, Takahashi K: Late onset of vaccine-associated measles in an adult with severe clinical symptoms: a case report., Am J Med., 127:e3-4, 2014
  7. Matsui M, Shindo K, Izumi T, Io K, Shinohara M, Komano J, Kobayashi M, Kadowaki N, Harris RS, Takaori-Kondo A: Small molecules that inhibit Vif-induced degradation of APOBEC3G., Virol J., 11:122, 2014
  8. Takeda S, Kanbayashi D, Kurata T, Yoshiyama H, Komano J: Enhanced susceptibility of B lymphoma cells to measles virus by EBV type III latency that up-regulates CD150/SLAM., Cancer Sci., 105:211-218, 2014

2013年

  1. Kawano H, Miyamoto K, Sakaguchi I, Myojin T, Moriwaki M, Tsuchiya T, Tanabe T, Yamamoto S, Tsujibo H: Role of periplasmic binding proteins, FatB and VatD, in the vulnibactin utilization system of Vibrio vulnificus M2799., Microb. Pathog., 65:73-81, 2013
  2. Funahashi T, Tanabe T, Miyamoto K, Tsujibo H, Maki J, Yamamoto S: Characterization of a gene encoding the outer membrane receptor for ferric enterobactin in Aeromonas hydrophila ATCC 7966(T)., Biosci. Biotechnol. Biochem., 77:353-360, 2013
  3. Funahashi T, Tanabe T, Maki J, Miyamoto K, Tsujibo H, Yamamoto S: Characterization of Vibrio parahaemolyticus genes encoding the systems for utilization of enterobactin as a xenosiderophore., Microbiol., 159:678-690, 2013
  4. Urano E, Morikawa Y, Komano J: Novel role of HSP40/DNAJ in the regulation of HIV-1 replication., J Acquir Immune Defic Syndr., 64:154-162, 2013
  5. Nomura W, Aikawa H, Ohashi N, Urano E, Métifiot M, Fujino M, Maddali K, Ozaki T, Nozue A, Narumi T, Hashimoto C, Tanaka T, Pommier Y, Yamamoto N, Komano JA, Murakami T, Tamamura H: Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products., ACS Chem Biol., 8:2235-2244, 2013
  6. Lee H, Komano J, Saitoh Y, Yamaoka S, Kozaki T, Misawa T, Takahama M, Satoh T, Takeuchi O, Yamamoto N, Matsuura Y, Saitoh T, Akira S: Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus., Proc Natl Acad Sci U S A, 110:12379-12384, 2013
  7. Tanaka A, Takeda S, Kariya R, Matsuda K, Urano E, Okada S, Komano J: A novel therapeutic molecule against HTLV-1 infection targeting provirus., Leukemia, 27:1621-1627, 2013
  8. Kojima Y, Kawahata T, Mori H, Furubayashi K, Taniguchi Y, Iwasa A, Taniguchi K, Kimura H, Komano J: Prevalence and epidemiological traits of HIV infections in populations with high-risk behaviours as revealed by genetic analysis of HBV., Epidemiol Infect., 141:2410-2417, 2013

2012年

  1. Tanabe T, Funahashi T, Shiuchi K, Okajima N, Nakao H, Miyamoto K, Tsujibo H, Yamamoto S: Characterization of Vibrio parahaemolyticus genes encoding the systems for utilization of enterobactin as a xenosiderophore., Microbiol., 158:2039-2049, 2012
  2. Funahashi T, Tanabe T, Mihara K, Miyamoto K, Tsujibo H, Yamamoto S: Identification and characterization of an outer membrane receptor gene in Acinetobacter baumannii required for utilization of desferricoprogen, rhodotorulic acid, and desferrioxamine B as xenosiderophores., Biol. Pharm. Bull., 35:753-760, 2012
  3. Tsuchiya T, Nakao N, Yamamoto S, Hirai Y, Miyamoto K, Tsujibo H: NK1.1(+) cells regulate neutrophil migration in mice with Acinetobacter baumannii pneumonia., Microbiol. Immunol., 56:107-116, 2012
  4. Zhang X, Sobue T, Isshiki M, Makino S, Inoue M, Kato K, Shioda T, Ohashi T, Sato H, Komano J, Hanabusa H, Shida H. Elicitation of both anti HIV-1 Env humoral and cellular immunities by replicating vaccinia prime Sendai virus boost regimen and boosting by CD40Lm. PLoS One, 7:e51633, 2012. doi: 10.1371/journal.pone.0051633. Epub 2012 Dec 7.
  5. Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S: Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1., Cell Host Microbe., 12:109-116, 2012
  6. Miyauchi K, Urano E, Takeda S, Murakami T, Okada Y, Cheng K, Yin H, Kubo M, Komano J: Toll-like receptor (TLR) 3 as a surrogate sensor of retroviral infection in human cells., Biochem Biophys Res Commun., 424:519-523, 2012
  7. Urano E, Miyauchi K, Ichikawa R, Futahashi Y, Komano J: Regulation of cyclin T1 expression and function by an alternative splice variant that skips exon 7 and contains a premature termination codon., Gene, 505:1-8, 2012
  8. Yanagita H, Fudo S, Urano E, Ichikawa R, Ogata M, Yokota M, Murakami T, Wu H, Chiba J, Komano J, Hoshino T: Structural modulation study of inhibitory compounds for ribonuclease H activity of human immunodeficiency virus type 1 reverse transcriptase., Chem Pharm Bull, 60:764-771, 2012
  9. Hashimoto C, Nomura W, Ohya A, Urano E, Miyauchi K, Narumi T, Aikawa H, Komano JA, Yamamoto N, Tamamura H: Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines., Bioorg Med Chem., 20:3287-3291, 2012
  10. Watanabe T, Urano E, Miyauchi K, Ichikawa R, Hamatake M, Misawa N, Sato K, Ebina H, Koyanagi Y, Komano J: The hematopoietic cell-specific Rho GTPase inhibitor ARHGDIB/D4GDI limits HIV type 1 replication., AIDS Res Hum Retroviruses, 28:913-922, 2012

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